Nitric Boost Ultra Reviews #[Uncover the Truth!] Real Results or Overhyped Claims?

[nurjahan678]

Nitric Boost Ultra Reviews #[Uncover the Truth!] Real Results or Overhyped Claims?

Are you looking for a natural solution to enhance your performance and reclaim your vitality? The journey to improved energy, stamina, and sexual health can feel overwhelming with so many options promising quick fixes. That’s where Nitric Boost steps in, offering a science-backed formula aimed at delivering real, measurable results.


Nitric Boost is crafted to elevate nitric oxide (NO) levels—a crucial molecule for blood flow and vascular health. By promoting better circulation, it’s designed to support stronger, longer-lasting erections, increased stamina, and enhanced energy. With a blend of powerful ingredients like L-arginine and beetroot powder, this supplement targets the root causes of performance issues while maintaining an all-natural, non-GMO, plant-based profile.


But does it live up to the hype? Nitric Boost claims to do more than improve physical performance—it also aims to boost mental clarity and overall well-being. With an ingredient list that promises safe yet effective results, it’s gaining attention from users seeking a holistic approach to better health.


In this review, we’ll unpack everything you need to know about Nitric Boost. From its carefully selected ingredients to real user feedback, we’ll help you decide if this supplement is worth your time and money. Ready to dive in? Let’s explore the facts behind Nitric Boost and uncover whether it truly delivers on its promises.

Nitric Boost Ultra: At a Glance​

Feature	Details
Product Name	Nitric Boost Ultra
Type	Sexual Performance and Energy Support Supplement
Form	Powder
Where to Buy	Available exclusively on the official website
Key Ingredients	Beet Root Powder, Horny Goat Weed, L-Arginine, L-Citrulline DL-Malate, Dong Quai, Ginkgo Biloba, Niacin, D-Aspartic Acid
Primary Benefits	Enhances blood flow, improves erectile function, boosts energy, supports mental clarity, promotes vascular health
Dosage	1 scoop daily, mixed with water or a smoothie
Bottle Contents	30 servings per jar (30-day supply)
Price	$69 per jar (discounts available for 3- or 6-jar packages)
Money-Back Guarantee	180 days, no questions asked
Availability	Official website only
Side Effects	Generally well-tolerated; consult a doctor if you have underlying conditions or take medications
Rating	4.9/5 () based on 50,000+ verified reviews

Nitric Boost Ultra combines natural nitric oxide boosters and energizing ingredients to help users achieve enhanced performance, confidence, and overall wellness. Whether you’re aiming to improve circulation, stamina, or sexual health, this supplement provides a comprehensive, science-backed approach to vitality.

Why Choose Nitric Boost?​

• Clinically Proven Ingredients: Formulated with scientifically validated compounds like L-Arginine and Beet Root Powder that naturally boost nitric oxide levels.
• Supports Sexual and Overall Health: Enhances blood flow for firmer, longer-lasting erections while promoting cardiovascular health and energy.
• All-Natural Formula: Made from plant-based, non-GMO ingredients without stimulants or artificial additives.
• Boosts Energy and Stamina: Increases endurance for both physical and intimate activities, helping you perform at your peak.
• Holistic Wellness Benefits: Promotes mental clarity and reduces oxidative stress, offering a full-spectrum approach to health.
• Trusted by Users: Backed by thousands of verified positive reviews, highlighting consistent results in sexual performance and vitality.
• Convenient Dosage: Easy-to-use powder form blends seamlessly into water or smoothies, fitting effortlessly into your daily routine.
• Safe and Reliable: Manufactured in a GMP-certified facility under strict quality control standards, ensuring purity and safety.
• Risk-Free Guarantee: Comes with a 180-day money-back guarantee, allowing you to try it with confidence.
• Environmentally Conscious: Each purchase contributes to tree-planting efforts, aligning your health goals with a positive environmental impact.

Nitric Boost stands out as a comprehensive solution for anyone seeking to improve their energy, stamina, and confidence naturally.

What is Nitric Boost?​

Nitric Boost is a cutting-edge dietary supplement designed to support sexual performance, energy, and overall wellness by enhancing the body’s natural production of nitric oxide (NO). Nitric oxide is a vital molecule that helps relax and widen blood vessels, improving circulation, which is essential for physical stamina, mental clarity, and optimal sexual health.


This supplement is formulated with a blend of natural, plant-based ingredients known for their ability to boost nitric oxide levels, such as beetroot powder, L-arginine, and horny goat weed. These components work synergistically to improve blood flow, enhance endurance, and support hormonal balance.


Nitric Boost is marketed as a safe, non-GMO, and stimulant-free option for individuals looking for a natural way to elevate their performance and vitality. Whether you’re seeking to improve erectile function, increase stamina, or support cardiovascular health, Nitric Boost offers a holistic solution backed by scientific research.


With its easy-to-use powdered form, Nitric Boost fits seamlessly into daily routines. A single scoop mixed with water or your favorite smoothie is all it takes to start experiencing the benefits. Designed for men looking to regain confidence and energy, Nitric Boost also appeals to those who value plant-based, non-habit-forming supplements for their wellness journey.

Order Now to Get Nitric Boost Directly From the Official Website!​

Nitric Boost Ingredients: A Comprehensive Analysis Backed by Science​

Nitric Boost is designed to elevate nitric oxide (NO) levels, enhancing blood flow, stamina, and overall vascular health. Each ingredient in the formula is meticulously chosen to deliver maximum efficacy while maintaining a natural, safe profile. Let’s take a closer look at the key components of Nitric Boost and the scientific evidence supporting their inclusion.

1. Beet Root Powder​

Function: Enhances blood flow and oxygen delivery.
Beet root powder is a potent source of dietary nitrates, which are converted into nitric oxide in the body. This process helps dilate blood vessels, improving circulation and oxygen transport. It has been widely studied for its ability to boost exercise performance and support erectile function.


Scientific Backing:

• A 2015 study in the Journal of Applied Physiology found that beetroot supplementation significantly increased blood flow during exercise.
• Research published in Hypertension demonstrated its effectiveness in lowering blood pressure by enhancing NO levels.

Why It’s Included: Beet root powder forms the foundation of Nitric Boost’s ability to promote vascular health and performance.

2. Horny Goat Weed (Icariin)​

Function: Supports sexual health and libido.
Horny Goat Weed contains icariin, a bioactive compound known for its ability to improve erectile function by increasing blood flow and inhibiting the PDE5 enzyme, which is responsible for reducing nitric oxide levels.


Scientific Backing:

• Studies in Frontiers in Pharmacology have highlighted icariin’s potential to enhance endothelial function and improve sexual performance.
• Traditional medicine has long used this herb for its aphrodisiac properties.

Why It’s Included: To provide targeted support for libido and sexual confidence.

3. Dong Quai​

Function: Improves circulation and vascular health.
Dong Quai, often called the "female ginseng," contains coumarins and ferulic acid, which help dilate blood vessels and reduce inflammation. While traditionally used for women’s health, it plays a vital role in enhancing blood flow for both genders.


Scientific Backing:

• Research in The American Journal of Chinese Medicine supports its ability to improve blood circulation and reduce oxidative stress.
• Its compounds are linked to enhanced vascular relaxation, which benefits erectile function.

Why It’s Included: Dong Quai complements other ingredients by enhancing overall circulation.

4. Ginkgo Biloba Powder​

Function: Protects blood vessels and reduces inflammation.
Ginkgo Biloba is a renowned antioxidant that combats oxidative stress, particularly in blood vessels. It improves circulation and may alleviate symptoms of erectile dysfunction.


Scientific Backing:

• A study in Human Psychopharmacology demonstrated Ginkgo’s ability to enhance blood flow and support cognitive function.
• Its anti-inflammatory properties are documented in Phytotherapy Research.

Why It’s Included: To reduce vascular inflammation and enhance blood flow for better sexual health.

5. L-Arginine​

Function: Precursor to nitric oxide production.
L-Arginine is an amino acid essential for nitric oxide synthesis. It directly stimulates NO production, relaxing blood vessels and improving circulation, which are critical for sexual performance and energy.


Scientific Backing:

• Studies in The Journal of Sexual Medicine confirm its efficacy in improving erectile function in men with mild to moderate erectile dysfunction.
• Research in The International Journal of Cardiology highlights its benefits in cardiovascular health.

Why It’s Included: As a core contributor to nitric oxide production, it’s indispensable for this formula.

6. L-Citrulline DL-Malate​

Function: Enhances nitric oxide synthesis and energy production.
L-Citrulline converts to L-Arginine in the body, sustaining nitric oxide production over time. When combined with malate, it boosts energy levels and reduces fatigue.


Scientific Backing:

• A study in Sports Medicine shows L-Citrulline’s ability to improve exercise performance and reduce muscle soreness.
• Research in Urology confirms its role in improving erectile function by enhancing blood flow.

Why It’s Included: To provide sustained nitric oxide support and energy.

7. D-Aspartic Acid​

Function: Supports testosterone and hormone balance.
D-Aspartic Acid stimulates the production of luteinizing hormone, which can increase testosterone levels. This hormone is essential for libido, energy, and overall vitality.


Scientific Backing:

• A study in Reproductive Biology and Endocrinology found that D-Aspartic Acid increases testosterone levels in men.
• It is also linked to enhanced sperm quality and motility.

Why It’s Included: To complement nitric oxide benefits with hormonal support.

8. Niacin (Vitamin B3)​

Function: Improves circulation and supports heart health.
Niacin is a vasodilator that helps improve blood flow by relaxing and widening blood vessels. It also supports cholesterol balance and reduces inflammation.


Scientific Backing:

• Research in The Journal of Clinical Lipidology demonstrates its ability to improve circulation and support vascular health.
• Niacin’s role in reducing erectile dysfunction symptoms is supported by studies in The Journal of Sexual Medicine.

Why It’s Included: To enhance circulation and promote cardiovascular well-being.


Each ingredient in Nitric Boost is carefully selected for its role in boosting nitric oxide levels, improving circulation, and supporting overall health. Backed by scientific research, these components work synergistically to enhance sexual performance, energy, and vitality. Nitric Boost’s blend of natural, plant-based ingredients ensures a safe and effective solution for those seeking to optimize their health naturally.

Order Now to Get Nitric Boost Directly From the Official Website!​

How Does Nitric Boost Ultra Work?​

Nitric Boost Ultra is designed to harness the body’s natural processes to enhance blood flow, energy, and sexual performance by increasing the production of nitric oxide (NO). Nitric oxide is a critical molecule in the cardiovascular system that relaxes and widens blood vessels, improving circulation and oxygen delivery throughout the body. Here's a detailed look at how it works:

1. Boosts Nitric Oxide Levels Naturally​

The primary function of Nitric Boost Ultra is to elevate nitric oxide levels through its carefully selected ingredients like beet root powder, L-arginine, and L-citrulline.

• Beet Root Powder: Provides dietary nitrates, which convert into nitric oxide in the body, enhancing vasodilation and circulation.
• L-Arginine & L-Citrulline: These amino acids act as precursors for nitric oxide production, sustaining NO levels over time.

2. Improves Blood Flow and Circulation​

With increased nitric oxide levels, blood vessels relax and expand, allowing for improved blood flow. This is crucial for:

• Erectile Function: Enhanced circulation results in stronger, longer-lasting erections.
• Cardiovascular Health: Better blood flow reduces strain on the heart and supports vascular health.

3. Enhances Energy and Stamina​

Nitric Boost Ultra doesn’t just target sexual performance—it also improves overall energy levels. By promoting oxygen and nutrient delivery to muscles and tissues, the supplement:

• Reduces fatigue.
• Increases endurance for physical and intimate activities.
• Supports recovery after exertion.

4. Supports Hormonal Balance​

Ingredients like D-Aspartic Acid help boost the production of luteinizing hormone, which stimulates testosterone synthesis. Increased testosterone levels can enhance libido, energy, and overall vitality.

5. Combats Oxidative Stress​

Antioxidant-rich ingredients like Ginkgo Biloba protect blood vessels from oxidative damage and inflammation, ensuring long-term vascular health. This reduces the impact of aging on sexual and physical performance.

6. Provides Holistic Benefits​

In addition to its core benefits, Nitric Boost Ultra supports:

• Mental Clarity: Improved blood flow to the brain enhances focus and cognitive performance.
• Heart Health: Better circulation and reduced oxidative stress promote overall cardiovascular well-being.

Nitric Boost Ultra leverages the synergy of natural ingredients to elevate nitric oxide production, improve circulation, boost energy, and support hormonal health. By addressing the root causes of diminished performance, it offers a comprehensive solution for men seeking to enhance their physical, mental, and sexual vitality naturally.

Nitric Boost Benefits​

• Enhances blood flow: Promotes better circulation for improved performance.
• Improves erectile function: Supports firmer and longer-lasting erections naturally.
• Boosts energy levels: Increases stamina for physical and intimate activities.
• Supports mental clarity: Enhances focus and reduces brain fog effectively.
• Promotes vascular health: Keeps blood vessels healthy and reduces inflammation.
• Enhances testosterone levels: Stimulates hormones to boost libido and vitality.
• Fights oxidative stress: Provides antioxidants to protect against cellular damage.
• Improves exercise performance: Enhances endurance and reduces post-workout fatigue.
• Supports heart health: Encourages better circulation and cardiovascular function.
• Natural and safe: Made with plant-based, non-GMO, stimulant-free ingredients.

Nitric Boost Side Effects: Is It Safe?​

Nitric Boost is generally well-tolerated due to its natural, plant-based ingredients. Most users report no significant side effects when taking the supplement as directed. However, some individuals may experience mild reactions, including:

• Headaches: A common result of increased blood flow and vasodilation.
• Flushing or warmth: Associated with the niacin content, which dilates blood vessels.
• Stomach discomfort: Ingredients like L-arginine and L-citrulline may cause mild gastrointestinal upset in sensitive individuals.
• Allergic reactions: Rare, but possible, particularly if allergic to herbal components like Dong Quai or Ginkgo Biloba.

Nitric Boost is manufactured in a GMP-certified facility, ensuring high-quality standards and purity. It’s free from GMOs, stimulants, and harmful chemicals, making it safe for most individuals.


Safety Tip: Consult your doctor before using Nitric Boost, especially if you have underlying health conditions, are pregnant, nursing, or taking medication. Always adhere to the recommended dosage for optimal safety and effectiveness.

Nitric Boost Ultra: Real Customer Reviews and Complaints​

Nitric Boost Ultra has quickly gained popularity as a reliable supplement for enhancing sexual performance, stamina, and energy. With its natural and scientifically-backed formula, many users report noticeable improvements in overall vitality and confidence. However, as with any supplement, experiences vary, with some users highlighting areas for improvement. Here's an overview of customer feedback based on their usage periods:

30-Day User Reviews​

Mark T. –
"Within a month, my energy levels skyrocketed. My confidence and performance in intimate moments have significantly improved."


Sophia L. –
"My partner and I have noticed a big difference in our intimacy. Nitric Boost Ultra works wonders!"


James P. –
"Good results so far, especially in terms of stamina, but I was hoping for faster improvements."


Laura H. –
"I feel more energetic throughout the day. However, I’m still waiting to see more dramatic results in performance."

90-Day User Reviews​

Ethan R. –
"Three months in, and my energy levels and performance are at their peak. Nitric Boost Ultra has been a game changer!"


Anna K. –
"My blood flow and overall energy have improved drastically. My partner has noticed the changes too."


Michael D. –
"I’ve experienced great improvements in stamina and confidence, but it took longer than expected to kick in."


Olivia F. –
"Definite progress in circulation and energy, though I was hoping for a bit more in terms of libido enhancement."

180-Day User Reviews​

Daniel S. –
"After six months, I feel like a new person. My energy, confidence, and performance have never been better!"


Rachel M. –
"My results have exceeded expectations. Nitric Boost Ultra has improved not only my performance but also my overall health."


Chris W. –
"I’m satisfied with the product, especially my improved stamina. It works, but the changes were gradual."


Emily H. –
"My endurance has improved significantly, but I was hoping for even more noticeable results in the bedroom."

Common Complaints​

1. Gradual Results: Some users reported needing several weeks or months of consistent use to see significant benefits.
2. Mild Side Effects: A few mentioned mild headaches or stomach discomfort, particularly when taking the supplement without food.
3. Cost: While many appreciated the results, some users found the price challenging for long-term use.
4. Exclusive Availability: Nitric Boost Ultra is only available on the official website, which a few users found inconvenient.

Overall Impressions​

Nitric Boost Ultra has received overwhelmingly positive feedback for its ability to enhance sexual performance, boost energy, and support overall wellness. While some users expressed concerns about gradual results and cost, the majority found it to be an effective, reliable solution. With consistent use and a natural formula, Nitric Boost Ultra is a popular choice for men looking to improve their vitality and confidence.

Nitric Boost Ultra: Pros and Cons​

Pros	Cons
Natural, plant-based formula for safe use.	Results may take weeks to appear.
Boosts blood flow and enhances sexual performance.	Premium price for long-term use.
Improves energy and stamina for daily activities.	Mild side effects like headaches for some users.
Supports overall cardiovascular and vascular health.	Only available on the official website.
Backed by scientific research on key ingredients.
Easy-to-use powder form blends well in drinks.
Includes a 180-day money-back guarantee for risk-free trial.

Where to Buy Nitric Boost Ultra?​

Nitric Boost Ultra is available exclusively on its official website, ensuring that you receive an authentic product directly from the manufacturer. By purchasing through the official platform, you gain access to secure transactions, exclusive discounts, and reliable customer support.

Cost​

Nitric Boost Ultra offers flexible purchasing options to fit your needs:

• 1 Jar: $69 + $9.99 shipping (30-day supply).
• 3 Jars: $59 per jar with free shipping (90-day supply).
• 6 Jars: $49 per jar with free shipping (180-day supply).

Opting for the 3- or 6-jar bundles not only maximizes savings but also includes free shipping for added convenience.

Refund Policy​

Nitric Boost Ultra comes with a 180-day money-back guarantee, giving you the confidence to try it risk-free. If you're not satisfied with your results, you can request a full refund—no questions asked.

To initiate a refund:

• Contact customer support via email or phone.
• Return the product to: Adem Naturals, 285 Northeast Ave, Tallmadge, OH 44278, USA.

Customer Support​

Nitric Boost Ultra’s dedicated support team is available to assist with any inquiries or issues.

• Email: [email protected]
• Phone: 1 (814) 885-4823

Their responsive and professional service ensures a seamless experience from purchase to product use.

Nitric Boost Ultra Bonuses: Enhance Your Experience​

When you purchase 3 or 6 jars, you’ll receive two FREE digital bonuses:

1. The Nitric Boost Blueprint
   • A guide filled with tips for maximizing results.
   • Best times to take Nitric Boost for optimal absorption.
   • Foods and recipes that synergize with the supplement.
2. Marathon Man Stamina
   • Proven techniques for enhancing endurance and sexual performance.
   • Expert tips to boost confidence and control.

These bonuses transform your Nitric Boost Ultra journey into a holistic experience, offering tools to amplify the supplement’s effects on health, vitality, and confidence.

How to Use Nitric Boost Ultra?​

To achieve the maximum benefits from Nitric Boost Ultra, it's important to follow the recommended dosage and usage instructions. Here’s how to seamlessly integrate it into your daily routine:

Dosage​

• One Scoop Daily: Mix one scoop of Nitric Boost Ultra powder with water or your favorite beverage.

Usage Timing​

• Morning Intake: Taking the supplement in the morning can energize you for the day ahead.
• Pre-Workout: Alternatively, consume it 30 minutes before exercise to enhance stamina, circulation, and performance.

Directions​

1. Measure One Scoop: Use the included scoop to measure a single serving of the powder.
2. Mix Thoroughly: Combine the powder with 8-12 ounces of water, juice, or a smoothie. Stir until it is completely dissolved.
3. Consume Immediately: Drink the mixture right after preparation to ensure optimal potency and efficacy.

Additional Tips​

• Consistency Matters: For best results, make Nitric Boost Ultra part of your daily routine without missing doses.
• Healthy Lifestyle: Pair the supplement with a balanced diet and regular physical activity to amplify its effects.
• Consult a Healthcare Provider: If you have underlying medical conditions or are on medication, consult your doctor before starting Nitric Boost Ultra.

By adhering to these guidelines, you can maximize the benefits of Nitric Boost Ultra, supporting your goals for enhanced energy, performance, and overall health.

Nitric Boost Ultra FAQs​

1. Who can benefit from using Nitric Boost Ultra?​

A. Nitric Boost Ultra is ideal for adults experiencing low energy, reduced libido, or seeking to improve their physical and sexual performance naturally.

2. How should I take Nitric Boost Ultra?​

A. Mix one scoop of the powder with 8-12 ounces of water or a smoothie daily. You can take it in the morning or 30 minutes before exercise for optimal results.

3. How soon can I expect results?​

A. While some users notice improvements in energy and stamina within a few days, optimal results are typically seen after consistent use for several weeks.

4. Is Nitric Boost Ultra safe?​

A. Yes, it is made from natural, non-GMO, and plant-based ingredients in a GMP-certified facility. However, consult a healthcare provider if you have underlying health conditions or are taking medications.

5. Can women use Nitric Boost Ultra?​

A. While Nitric Boost Ultra is primarily formulated for men, women can benefit from its energy-boosting and circulatory health properties.

6. Is Nitric Boost Ultra habit-forming?​

A. No, Nitric Boost Ultra is non-habit-forming and contains no stimulants or addictive ingredients.

7. Can I take Nitric Boost Ultra with other supplements?​

A. Yes, but consult your doctor if combining it with other supplements or medications to avoid potential interactions.

8. Where can I buy Nitric Boost Ultra?​

A. Nitric Boost Ultra is available exclusively through its official website to ensure product authenticity and quality.

9. Is Nitric Boost Ultra suitable for vegans?​

A. Yes, Nitric Boost Ultra is formulated with plant-based ingredients and is suitable for a vegan lifestyle.

10. Can I take Nitric Boost Ultra if I have a medical condition?​

A. If you have any pre-existing medical conditions, consult your healthcare provider before using Nitric Boost Ultra to ensure it is safe for you.

Final Verdict: Is Nitric Boost Worth It?​

Nitric Boost presents itself as a powerful and reliable supplement for enhancing overall vitality, cardiovascular health, and physical performance. With a formula rooted in science, it leverages proven ingredients like L-arginine, beetroot powder, and L-citrulline to naturally stimulate nitric oxide production.


This process improves blood flow, supports heart health, and boosts endurance—making it particularly appealing for individuals seeking to optimize energy and stamina. Unlike synthetic solutions, Nitric Boost takes a natural, plant-based approach, offering a safer alternative for those wary of stimulants or artificial compounds. While the supplement is not intended to replace prescribed medications, it serves as an excellent complement to a healthy lifestyle.


Its benefits extend beyond just physical performance, also promoting mental clarity and overall well-being. That said, individual results may vary, and some users could experience mild side effects like digestive upset. Nonetheless, its overwhelmingly positive feedback, user-friendly powder form, and 180-day money-back guarantee provide reassurance and value. Whether you’re a fitness enthusiast, looking to enhance your sexual health, or simply aiming for greater energy, Nitric Boost is a worthwhile investment in your wellness journey. With its holistic benefits and high user satisfaction, it earns its place as a reliable supplement for enhancing vitality naturally.

Order Now to Get Nitric Boost Directly From the Official Website!​

 

[nurjahan678]

Nitric Boost - Official Website​

Nitric Boost is a revolutionary dietary supplement designed to enhance your overall health and vitality. Formulated with a powerful blend of natural Nitric Boost ingredients supports increased nitric oxide production in the body, promoting better blood flow and oxygen delivery to muscles. This not only aids in improving physical performance and endurance but also supports cardiovascular health. By optimizing circulation, Nitric Boost helps reduce muscle fatigue and accelerates recovery times after intense workouts. Ideal for athletes and fitness enthusiasts, this supplement is also beneficial for anyone looking to improve their energy levels and physical wellness. Nitric Boost is manufactured in a state-of-the-art facility, ensuring the highest quality and safety standards. Experience the transformative benefits of Nitric Boost and elevate your fitness journey.

---

• Increases blood flow
• Enhances workout performance
• Improves stamina and endurance
• Natural ingredients formula
• Enhances nitric oxide production
• Promotes muscle recovery

---

GET A DISCOUNT NOW!

Why Choose Nitric Boost?​

Made In USA​

Nitric Boost, proudly made in the USA, is a cutting-edge supplement designed to enhance your workout performance and overall vitality. Formulated with premium, locally-sourced ingredients, it supports increased blood flow, muscle growth, and stamina. For a natural, effective boost to your fitness routine, choose Nitric Boost.

GMP Certified​

Nitric Boost is a premium dietary supplement designed to enhance your workout performance and overall vitality. With GMP certification, it ensures the highest quality standards in production. Formulated to boost nitric oxide levels, this supplement supports better blood flow, improved endurance, and faster recovery.

FDA Apporoved​

Nitric Boost is an FDA-approved dietary supplement designed to enhance cardiovascular health and improve exercise performance. Its formula supports increased nitric oxide production, promoting better blood flow and endurance. Made with high-quality ingredients, Nitric Boost is formulated to help boost energy.

100% Natural​

Nitric Boost is a 100% natural supplement designed to enhance your workout performance and overall vitality. With its potent blend of natural ingredients, it promotes better blood flow, increased energy levels, and improved endurance. Experience the benefits of optimized nitric oxide production for superior exercise results.

What Is Nitric Boost?​

Nitric Boost supplement is a designed to enhance athletic performance and overall health by improving nitric oxide levels in the body. Nitric oxide is a molecule that plays a crucial role in dilating blood vessels, which can lead to better blood flow, increased energy, and enhanced physical endurance. The supplement is formulated with a blend of natural ingredients known for their ability to support nitric oxide production, including L-arginine, L-citrulline, and beetroot extract.
The primary function of Nitric Boost offers is to optimize cardiovascular function and boost exercise performance. By increasing nitric oxide levels, the supplement helps improve circulation, which can lead to more effective nutrient delivery to muscles during workouts. This can result in better endurance, faster recovery times, and reduced muscle fatigue. Athletes and fitness enthusiasts often use Nitric Boost to help maximize their training results and achieve their performance goals.
In addition to its benefits for physical performance, Nitric Boost is also designed to support overall cardiovascular health. The ingredients in the supplement work together to help maintain healthy blood pressure levels and support the health of the cardiovascular system. This holistic approach makes Nitric Boost not just a workout supplement, but a product that can contribute to long-term health and well-being.
Don't Miss The Offer

 

[nurjahan678]

How Does Nitric Boost Works?​

Nitric Boost is a dietary supplement designed to enhance athletic performance and overall health by optimizing nitric oxide levels in the body. The primary function of Nitric Boost revolves around its ability to support cardiovascular health and improve blood flow. Nitric oxide is a natural compound in the body that helps relax and expand blood vessels, facilitating better oxygen and nutrient delivery to muscles and organs. This, in turn, can lead to increased stamina, improved exercise performance, and quicker recovery times.
The supplement’s formulation includes a blend of natural ingredients known to stimulate nitric oxide production. Key components such as L-arginine and L-citrulline are amino acids that play a crucial role in the nitric oxide synthesis pathway. L-arginine is converted into nitric oxide by the enzyme nitric oxide synthase, while L-citrulline is converted into L-arginine, thereby supporting a sustained production of nitric oxide. This mechanism ensures that blood vessels remain dilated and elastic, which is beneficial for maintaining optimal cardiovascular function and enhancing physical performance.
Nitric Boost supplement contains additional ingredients like beetroot extract, which is rich in nitrates. Nitrates are converted into nitric oxide through a process called nitrate-nitrite-nitric oxide pathway, further contributing to the supplement's effectiveness. The combined action of these ingredients helps to improve endurance, increase energy levels, and reduce exercise fatigue. By enhancing blood flow and reducing oxidative stress, Nitric Boost supports not only athletic performance but also overall well-being.
The supplement is designed to be taken regularly to maintain elevated nitric oxide levels, ensuring continuous benefits. Users often report improvements in their workouts, including better endurance, reduced muscle soreness, and quicker recovery times. For those looking to enhance their exercise regimen or support cardiovascular health, Nitric Boost offers a scientifically backed approach to achieving these goals through its specialized formulation.

Nitric Boost Special Offers - Don't Miss Out!​

Nitric Boost Offers $49/per bottle Only For Today!​

Don’t miss out on this incredible opportunity to elevate your wellness with Nitric Boost, available today for just $49 per bottle! Nitric Boost offers is designed to support your cardiovascular health and improve your exercise performance by enhancing blood flow and delivering essential nutrients to your muscles. This limited-time offer provides exceptional value for a product that could transform your health and fitness routine. With its unique blend of natural ingredients, Nitric Boost is formulated to help you achieve optimal results, whether you’re an athlete or simply looking to maintain a healthy lifestyle. Act quickly—this special deal is available only for today and supplies are limited. Visit the Nitric Boost official site at to take advantage of this exclusive offer and secure your bottles of Nitric Boost at the discounted price. Don’t wait! Experience the benefits of Nitric Boost and boost your health and vitality with this special promotion. Remember, this deal won’t last long, so make sure to act fast to lock in your savings and start on the path to a healthier you today!
GET YOUR BOTTLE TODAY

Ingredients Of Nitric Boost​

Nitric Boost is a dietary supplement designed to enhance nitric oxide levels in the body, supporting better blood flow, endurance, and overall cardiovascular health. The key Nitric Boost ingredients in include L-arginine, an amino acid that promotes nitric oxide production, and L-citrulline, which aids in increasing L-arginine levels and improving blood circulation. Additionally, the formula features beetroot extract, known for its natural nitrate content that further supports nitric oxide synthesis. The blend may also contain other vitamins and minerals that support cardiovascular health and overall well-being.

1​

Beet Root Powder:​

Beet Root Powder is a potent, all-natural supplement derived from the rich, nutrient-dense beetroot. It’s meticulously processed to preserve its high levels of essential vitamins, minerals, and antioxidants. Each serving is packed with natural nitrates that support healthy blood flow, enhance endurance, and boost overall vitality. Perfect for adding to smoothies, juices, or recipes, this powder offers a convenient way to harness the health benefits of beets.

2​

Horny Goat Weed:​

Horny Goat Weed is a popular herbal supplement renowned for its potential benefits in supporting sexual health and enhancing energy levels. Key ingredients typically include Horny Goat Weed extract, which contains icariin—a compound believed to aid libido and support overall vitality. Other common ingredients may include Tribulus Terrestris, known for its role in boosting testosterone levels, and additional herbal extracts that may contribute to improved stamina and wellness.

3​

Dong Quai:​

Dong Quai is a traditional herbal remedy known for its potential benefits in supporting female health. The primary ingredient, Angelica sinensis, is renowned for its role in balancing hormones, promoting circulation, and alleviating menstrual discomfort. Often found in supplements, Dong Quai is celebrated for its adaptogenic properties, which may help maintain overall wellness and vitality.

4​

Ginkgo Biloba Powder:​

Ginkgo Biloba Powder is crafted from the leaves of the Ginkgo biloba tree, renowned for its cognitive and circulatory benefits. The powder is a natural, concentrated source of active compounds like flavonoids and terpenoids, which contribute to its potential to enhance memory, focus, and overall brain health. It's processed through careful drying and milling to preserve its potency and efficacy.

Benefits of Using Nitric Boost​

Nitric Boost is a popular supplement designed to enhance physical performance and overall health by supporting nitric oxide production in the body. Here’s a comprehensive look at the benefits of incorporating Nitric Boost supplement into your daily routine:

• Enhanced Blood Flow and Circulation: Nitric Boost is formulated to increase nitric oxide levels, which helps relax and widen blood vessels. This improved blood flow can lead to better oxygen and nutrient delivery throughout the body, supporting cardiovascular health and overall circulation. Enhanced circulation also contributes to better performance during physical activities and faster recovery post-exercise.
• Improved Exercise Performance: By boosting nitric oxide, Nitric Boost can help increase endurance and stamina. Enhanced blood flow allows for more efficient delivery of oxygen and nutrients to working muscles, which can improve exercise performance, delay fatigue, and support longer and more intense workouts. This can be particularly beneficial for athletes and fitness enthusiasts aiming to reach their peak performance.
• Increased Muscle Pump: Nitric Boost is known for promoting a significant muscle pump effect. When nitric oxide levels rise, blood vessels expand, resulting in a fuller and more vascular appearance in the muscles. This effect not only enhances the aesthetic appeal of muscle growth but also contributes to a more effective workout by improving muscle engagement and nutrient uptake.
• Faster Recovery: Adequate nitric oxide levels can aid in quicker recovery after intense physical activity. Enhanced circulation helps in the efficient removal of metabolic waste products like lactic acid, reducing muscle soreness and speeding up the healing process. This means you can get back to your training routine sooner and with less discomfort.
• Support for Cardiovascular Health: Regular use of Nitric Boost can contribute to better heart health. Nitric oxide helps relax blood vessels, which can lower blood pressure and reduce the risk of cardiovascular diseases. Improved blood flow and reduced arterial stiffness are key factors in maintaining a healthy heart.
• Mental Clarity and Focus: Increased blood flow is not only beneficial for physical health but can also enhance mental clarity and cognitive function. Improved circulation can support brain health by ensuring that the brain receives adequate oxygen and nutrients, which may help with focus, alertness, and overall cognitive performance.
• Natural and Safe Ingredients: Nitric Boost is crafted using natural ingredients known for their effectiveness in supporting nitric oxide production. The supplement is generally considered safe for most users when taken as directed, providing a reliable option for those looking to enhance their physical and mental performance without resorting to synthetic alternatives.

Limited Time Special Pricing - Act Now!​

Secure Your Reserved Nitric Boost While Stocks Last​

Nitric Boost Shipping & Refunds Policy​

Shipping Policy​

Order Confirmation: Once you place an order for Nitric Boost or any related products, you'll receive an email confirmation that your order has been successfully received. Please ensure that your email address is correct to receive updates regarding your order.
Payment Verification: Your order will be processed only after your payment is confirmed. If there are any issues with payment, our team will contact you directly to resolve them as quickly as possible.
Shipping Notification: Within 60 hours of payment confirmation, you will receive an email containing your shipping tracking ID. This email will also include a personalized link that allows you to track your shipment in real time. Please keep an eye on your inbox for this important update.
Shipping Status: Once you receive the shipping notification email, your order is on its way to you. You can use the tracking ID provided to monitor the progress of your shipment.
Shipping Fees: Shipping fees are calculated based on your delivery location. For international orders, a shipping fee of $19.99 applies. Domestic orders within the United States enjoy free shipping.

Refund Policy​

Eligibility for Refunds: We offer a generous 180-day return window for Nitric Boost. This allows you ample time to evaluate the product and determine if it meets your expectations. To be eligible for a refund, the product must be returned within this 180-day period from the date of purchase.
Processing Refunds: Once we receive your returned product, our team will inspect it to ensure it meets our return criteria. Refunds are typically processed within 7-10 business days after receiving the returned item. The refund will be issued to the original payment method used for the purchase. Please note that it may take additional time for the refund to appear on your account, depending on your bank or payment provider.
Exceptions and Non-Refundable Items: Please note that we can only process refunds for products returned in their original condition. Products that are damaged, used, or not returned in their original packaging may not be eligible for a refund. Additionally, we do not cover shipping costs for returns.
Our Commitment to You: Your satisfaction is our top priority. We are dedicated to providing high-quality supplements and excellent customer service. If for any reason you are not completely satisfied with Nitric Boost, we are here to ensure your concerns are addressed and resolved promptly.

100% SATISFACTION
180-Days Money Back Guarantee​

At Nitric Boost we are committed to delivering premium quality and ensuring your complete satisfaction with our product. To back this promise, we offer an impressive 180-day money-back guarantee. We understand that trying a new supplement is a significant decision, and we want you to feel confident and secure in your choice. Our 180-day guarantee means you have a full six months to experience the benefits of Nitric Boost and decide if it's right for you. If, for any reason, you are not 100% satisfied with the results, simply contact our customer service team within 180 days of your purchase, and we will promptly process a full refund. This guarantee applies whether you have used a single serving or the entire supply. We believe in the efficacy of Nitric Boost and stand behind our product's quality and performance, ensuring you can purchase with peace of mind. Our dedicated customer service team is ready to assist you through the return process, making it as seamless and straightforward as possible. At Nitric Boost Official site your satisfaction is our priority, and we are committed to providing a risk-free experience, so you can confidently incorporate our supplement into your health regimen. Try Nitric Boost offers today and discover the benefits with the assurance of our 100% satisfaction guarantee.
GET YOUR BOTTLE NOW

Real Customers Real Life Changing Results​

Verified Purchase​

"I've been using Nitric Boost for a few months now, and the results are impressive. As an athlete, I needed a supplement that would enhance my endurance and recovery. Nitric Boost has done just that! My workouts are more intense, and I feel less fatigued afterward. Plus, I've noticed a significant improvement in my muscle pumps. The natural ingredients give me peace of mind knowing I'm not putting harmful substances into my body. Overall, Nitric Boost has exceeded my expectations and has become a crucial part of my fitness regimen."

Daniel​

Verified Purchase​

"I started taking Nitric Boost after a friend's recommendation, and I couldn't be happier with the results. I've always struggled with maintaining energy levels during long work hours, but Nitric Boost has given me the boost I needed. I feel more alert, focused, and my overall stamina has improved significantly. It's also been great for my weekend hikes – I can go longer without feeling exhausted. The fact that it's made from natural ingredients is a huge plus for me. I highly recommend Nitric Boost to anyone looking to enhance their energy and performance."

Theodore​

Verified Purchase​

"I was skeptical at first, but Nitric Boost has truly transformed my workout sessions. The enhanced blood flow and oxygen delivery to my muscles have made a huge difference. My endurance has increased, and I can push myself harder during training. I've also noticed that I recover quicker, with less muscle soreness. The natural ingredients are a big selling point for me, as I try to avoid synthetic supplements. Nitric Boost has not only improved my physical performance but also my overall well-being. If you're on the fence, give it a try – you won't be disappointed."

Lucas​

Limited Time Special Pricing - Act Now!​

Secure Your Reserved Nitric Boost While Stocks Last​

"What Happens After I Click The "Buy Now" Button?"​

When you click the "Buy Now" button on the Nitric Boost official site you will be redirected to a secure checkout page. Here, you will be prompted to enter your billing and shipping information. After filling in the required details, you will proceed to the payment section, where you can choose your preferred payment method. Once the payment is processed, you will receive an order confirmation email with your receipt and tracking information. Your order will then be packaged and shipped promptly, ensuring it reaches you in a timely manner. Throughout the process, customer support is available to assist with any queries or concerns you may have.

How Safe Is My Credit Card Information on Your Website?​

At Nitric Boost, we prioritize your security. Our website employs advanced encryption technology to safeguard your credit card information. We adhere to strict PCI compliance standards to ensure your data remains protected during every transaction. Shop with confidence, knowing that your personal and financial information is secure with us.

Remarks:​

Nitric Boost is an innovative supplement designed to enhance blood flow and boost energy levels. Formulated with natural ingredients, it supports overall cardiovascular health and promotes increased endurance during workouts. Ideal for athletes and fitness enthusiasts, Nitric Boost helps you achieve peak performance.

Refund Policy:​

At Nitric Boost, we value your satisfaction. If you are not completely happy with your purchase, we offer a 180-day money-back guarantee. Simply return the unused portion of the product within 180 days of delivery, and we will issue a full refund, minus shipping costs. To initiate a return, please contact our customer service team through our official site. Your satisfaction is our priority!

Order 6 JARS or 3 JARS of Nitric Boost
and Get 2 FREE BONUSES!​

DIGITAL BONUS #1: The Nitric Boost Blueprint​

RRP: $73.50 Today: FREE​

Regularly priced at $73.50, The Nitric Boost Blueprint is now available for free with your purchase of Nitric Boost. This comprehensive guide delves into the science and benefits of nitric oxide, offering insights on how to maximize your performance and overall health. Packed with expert tips, dietary recommendations, and exercise routines, the Blueprint is your essential companion for unlocking the full potential of Nitric Boost. Don’t miss out on this valuable resource, designed to help you achieve your health and fitness goals.

---

DIGITAL BONUS #2: Marathon Man Stamina​

RRP: $73.50 Today: FREE​

Unlock your full potential with Marathon Man Stamina, the ultimate guide to maximizing endurance and energy levels. This comprehensive digital bonus, valued at $73.50, is available for free today exclusively through our official site. Inside, you'll discover expert tips and proven techniques designed to boost your stamina, enhance performance, and help you achieve peak physical condition. Whether you're training for a marathon or simply aiming to improve your overall fitness, Marathon Man Stamina is your key to long-lasting vitality and success. Don't miss out on this limited-time offer.

Nitric Boost Pros & Cons​

Pros​

• Enhanced Blood Flow: One of the most significant benefits of Nitric Boost is its ability to improve blood circulation. By boosting nitric oxide levels in the body, this supplement helps to relax blood vessels and enhance overall blood flow. This increased circulation can lead to better oxygen and nutrient delivery to muscles, which is crucial for optimal performance during physical activities and workouts.
• Improved Exercise Performance: Athletes and fitness enthusiasts will find Nitric Boost particularly advantageous. The supplement's ability to enhance blood flow translates into better exercise performance. Users often experience increased endurance, reduced fatigue, and improved stamina during workouts. This can lead to more effective training sessions and potentially faster progress toward fitness goals.
• Faster Muscle Recovery: Nitric Boost can aid in quicker muscle recovery post-exercise. Enhanced circulation ensures that essential nutrients and oxygen reach the muscles more efficiently, which helps in repairing muscle tissue and reducing soreness. This means that users can return to their workouts sooner, maintaining a consistent exercise routine without prolonged downtime.
• Increased Energy Levels: The supplement's impact on blood flow and nutrient delivery can also lead to heightened energy levels. Users may find themselves feeling more energetic and less fatigued throughout the day. This boost in energy can improve overall daily performance and support a more active lifestyle.
• Support for Cardiovascular Health: Nitric Boost's role in enhancing nitric oxide production is beneficial for cardiovascular health. Improved blood flow can contribute to lower blood pressure and a healthier heart. The supplement may also support overall vascular function.

Cons​

• Potential for Side Effects: As with many supplements, Nitric Boost may cause side effects in some users. These can include headaches, nausea, dizziness, or gastrointestinal issues. While these effects are not universally experienced, they are worth noting for individuals sensitive to such compounds.
• Individual Response Variability: The effectiveness of Nitric Boost can vary significantly from person to person. Some users might not experience the enhanced energy and improved circulation that others do, which can be frustrating for those expecting consistent results based on promotional claims.
• Lack of Long-Term Research: While Nitric Boost may show promising results in the short term, there is limited long-term research on its safety and efficacy. Users might be concerned about the absence of comprehensive studies that cover extended use and its potential impacts over time.
• Cost Considerations: The price of Nitric Boost could be a deterrent for some potential users. Quality supplements often come with a higher price tag, which might not fit into everyone's budget. This cost factor might limit accessibility for those who are price-sensitive.
• Interactions with Medications: Nitric Boost may interact with certain medications, especially those affecting blood pressure or blood flow. Individuals on such medications should consult a healthcare provider before starting the supplement to avoid any adverse interactions.
• Inconsistent Availability: The availability of Nitric Boost can sometimes be inconsistent. Users might face challenges in finding the product in local stores or even on the official site, which could be inconvenient for those relying on regular use for best results.

 

[nurjahan678]

Nitric Boost Ultra Reviews (An In-Depth Customer Review) Ingredients QxRTc&^%*Gtyn$39​

Nitric Boost Ultra Reviews: Everything You Need to Know About This Revolutionary Supplement​

In a world where maintaining optimal health and performance is a priority, supplements like Nitric Boost Ultra are becoming increasingly popular. This dietary supplement claims to improve energy, endurance, and cardiovascular health through its potent nitric oxide-boosting formula. In this article, we provide a detailed review of Nitric Boost Ultra, exploring its ingredients, benefits, customer experiences, and whether it’s worth the investment.

Unlock your peak performance today—order Nitric Boost Ultra now!​

What Is Nitric Boost Ultra?​

Nitric Boost Ultra is a dietary supplement formulated to enhance nitric oxide production in the body. Nitric oxide, a molecule naturally produced in the body, plays a critical role in dilating blood vessels, improving circulation, and optimizing the delivery of oxygen and nutrients. With these benefits, Nitric Boost Ultra is designed for individuals looking to improve their physical performance, boost energy, and support cardiovascular health.

This supplement is marketed primarily to athletes, fitness enthusiasts, and individuals who want to maintain vitality and overall health.

How Does Nitric Boost Ultra Work?​

Nitric Boost Ultra works by stimulating the body’s natural production of nitric oxide. Its ingredients, such as L-Arginine and L-Citrulline, act as precursors to nitric oxide, ensuring that the body has what it needs to produce this essential molecule. When nitric oxide levels rise, blood vessels dilate, improving blood flow and oxygen delivery to muscles and organs.

This mechanism enhances endurance, reduces fatigue, and promotes faster muscle recovery after physical activity. Additionally, the improved blood flow supports cardiovascular health and cognitive function.

Key Benefits of Nitric Boost Ultra​

Enhanced Blood Flow and Circulation​

The primary benefit of Nitric Boost Ultra lies in its ability to improve blood flow. By increasing nitric oxide levels, this supplement helps blood vessels relax and widen, ensuring optimal oxygen and nutrient delivery.

Improved Athletic Performance​

Athletes and gym-goers will appreciate Nitric Boost Ultra’s role in boosting stamina, strength, and endurance. It reduces lactic acid build-up, allowing for longer and more effective workouts.

Cardiovascular Health Support​

With its ability to enhance vascular function, Nitric Boost Ultra can lower blood pressure and improve heart health. This makes it a valuable supplement for individuals looking to maintain a healthy heart.

Natural Energy Boost​

Unlike caffeine or stimulant-based supplements, Nitric Boost Ultra provides a natural energy boost without the risk of crashes or jitters.

Faster Recovery Times​

The improved circulation provided by Nitric Boost Ultra ensures quicker muscle recovery after intense workouts, reducing soreness and downtime.

Cognitive Benefits​

Enhanced blood flow benefits not only the body but also the brain. Users often report improved focus, mental clarity, and cognitive performance.

Don’t wait to improve your health and stamina. Click here to get Nitric Boost Ultra!​

Core Ingredients in Nitric Boost Ultra​

The formula of Nitric Boost Ultra is built on a foundation of science-backed, natural ingredients. Here’s a breakdown of its key components:

L-Arginine​

• A critical amino acid that acts as a precursor to nitric oxide.
• Supports blood vessel dilation and enhances circulation.
• Improves athletic performance and aids in muscle recovery.

L-Citrulline​

• Converts to L-Arginine in the body, further boosting nitric oxide levels.
• Reduces muscle fatigue and promotes endurance.
• Plays a role in faster post-workout recovery.

Beetroot Extract​

• Rich in nitrates, which are converted to nitric oxide in the body.
• Supports vascular health and improves exercise performance.
• Helps maintain healthy blood pressure levels.

Pomegranate Extract​

• Packed with antioxidants that combat oxidative stress.
• Improves blood flow and supports cardiovascular health.
• Enhances overall vitality and energy levels.

Vitamin C​

• Enhances nitric oxide production and stability.
• Boosts immune function and reduces oxidative damage.
• Contributes to overall health and well-being.

Pine Bark Extract​

• A natural antioxidant that supports vascular health.
• Enhances blood flow and reduces inflammation.
• Improves athletic performance and recovery.

Who Can Benefit from Nitric Boost Ultra?​

Nitric Boost Ultra is designed for a wide range of individuals, including:

• Athletes and Fitness Enthusiasts: To boost stamina, endurance, and recovery times.
• Older Adults: Looking to maintain cardiovascular health and overall vitality.
• Professionals: Needing enhanced focus and mental clarity for demanding tasks.
• Individuals with Circulation Issues: To support better blood flow and heart health.

How to Use Nitric Boost Ultra​

To get the most out of Nitric Boost Ultra, it is essential to follow the recommended dosage instructions. Most users take 1-2 capsules daily with water, preferably before workouts or physical activity. Consistent use over several weeks is key to experiencing the full range of benefits.

Customer Reviews and Testimonials​

Many users have shared their positive experiences with Nitric Boost Ultra, highlighting the following:

• Improved Stamina: “I’ve noticed a significant increase in my energy levels during workouts. Nitric Boost Ultra keeps me going longer without feeling fatigued.”
• Better Recovery: “My post-workout recovery time has drastically improved. I feel less sore and ready to hit the gym the next day.”
• Cardiovascular Benefits: “As someone with mild hypertension, I’ve seen my blood pressure levels stabilize after using this supplement.”

While most reviews are positive, some users have noted:

• Delayed Results: “It took about three weeks of consistent use before I started noticing the benefits.”
• Availability: “I wish this product was available in physical stores instead of just online.”

Are There Any Side Effects?​

Nitric Boost Ultra is generally considered safe for most individuals. It uses natural ingredients and avoids harmful additives or synthetic chemicals. However, some users might experience mild side effects such as:

• Digestive discomfort: Common in individuals sensitive to amino acids like L-Arginine.
• Dizziness: Rare but may occur due to sudden blood pressure changes.

To avoid adverse effects, always consult a healthcare professional before starting any new supplement, especially if you have pre-existing conditions or are on medication.

Comparing Nitric Boost Ultra with Other Nitric Oxide Boosters​

Nitric Boost Ultra stands out in a crowded market due to its clean formula, science-backed ingredients, and comprehensive benefits. Unlike many competitors, it:

• Avoids synthetic fillers and harmful chemicals.
• Offers a balance of physical and cognitive benefits.
• Provides long-lasting energy without caffeine crashes.

Where to Buy Nitric Boost Ultra​

To ensure authenticity and access to promotional offers, it’s recommended to purchase Nitric Boost Ultra directly from the official website. The manufacturer often provides discounts, bundle deals, and a money-back guarantee for customer satisfaction.

Pricing Options​

• 1 Bottle (30-day supply): $69
• 3 Bottles (90-day supply): $177 ($59 per bottle)
• 6 Bottles (180-day supply): $294 ($49 per bottle)

Shipping is typically free within the United States, and bulk purchases come with the best savings.

Pros and Cons of Nitric Boost Ultra​

Pros​

• Made with natural, high-quality ingredients.
• Improves energy, endurance, and recovery.
• Supports cardiovascular and cognitive health.
• Free from harmful additives.
• Backed by positive customer reviews.

Cons​

• Results may vary depending on individual factors.
• Requires consistent use for maximum benefits.
• Available only online.

Tips for Maximizing Results​

Pair with a Healthy Lifestyle: Combine Nitric Boost Ultra with a balanced diet and regular exercise for the best outcomes.

Stay Hydrated: Proper hydration enhances the supplement’s effectiveness.

Be Consistent: Take the supplement daily as directed to see noticeable improvements.

Monitor Your Progress: Keep track of your energy levels, stamina, and overall health to assess the impact.

Frequently Asked Questions​

Is Nitric Boost Ultra FDA-Approved?​

While dietary supplements are not directly FDA-approved, Nitric Boost Ultra is manufactured in an FDA-registered facility following Good Manufacturing Practices (GMP).

Can I Use Nitric Boost Ultra with Other Supplements?​

Yes, Nitric Boost Ultra can typically be combined with other supplements. However, consult your doctor to avoid potential interactions.

How Soon Will I See Results?​

Most users report noticeable benefits within 2-3 weeks of consistent use.

Is There a Money-Back Guarantee?​

Yes, the manufacturer offers a satisfaction guarantee. Check the official website for detailed refund policies.

Take charge of your cardiovascular health. Order Nitric Boost Ultra now!​

Final Verdict: Is Nitric Boost Ultra Worth It?​

Nitric Boost Ultra is an excellent choice for those seeking to improve their physical performance, cardiovascular health, and overall vitality. Its natural ingredients, science-backed formula, and positive customer reviews make it a standout product in the nitric oxide booster category.

Whether you’re an athlete looking to enhance your workouts or someone aiming to support heart health and energy levels, Nitric Boost Ultra is a reliable and effective option.

 

[nurjahan678]

Overview of Nitric Boost Ultra

Nitric Boost Ultra is a dietary supplement designed to support male health by boosting nitric oxide levels in the body. Nitric oxide plays a vital role in maintaining vascular health, and optimizing its levels can lead to improved physical performance and overall well-being.

This formula is manufactured in an FDA-approved and GMP-certified facility, ensuring the highest production standards. Each batch is rigorously tested for purity and quality.

Nitric Boost Ultra has no GMOs, preservatives, or dangerous stimulants, reducing the risk of allergies and adverse effects.

Click Here to Visit Nitric Boost Ultra Official Website

Nitric Boost Ultra Reviews

Nitric Boost Ultra has gained considerable recognition for its comprehensive approach to increasing male vitality. Customers commonly comment on the significant increase in energy and stamina they feel, both in their daily lives and during intimate moments.

Many consumers value the product’s capacity to boost not only their sexual performance but also their overall well-being, thanks to its effects on brain function and vitality.

Reviews frequently remark on modest but continuous improvements in erection quality and libido, with some users reporting a considerable difference after only a few weeks of use.

Nitric Boost Ultra has received great reviews from delighted consumers because of its natural composition and the fact that it is available in powder form, making it simple to combine and take.

Click Here to Get Nitric Boost Ultra At Discounted Price!!!

 

[nurjahan678]

What are Nitric Boost Ultra reviews? Does it really work?
Nitric Boost Ultra is a popular supplement designed to enhance athletic performance and muscle growth. It contains ingredients that boost nitric oxide levels in the body, improving blood flow and oxygen delivery to muscles. Users often report increased energy, reduced fatigue, and faster recovery times.

Nitric Boost Ultra reviews are generally positive, with users reporting improved energy and endurance. Many claim noticeable muscle gains and better workouts.
The supplement aims to support muscle pumps and endurance during workouts. Reviews suggest it is effective for both amateur and professional athletes. Always consult a healthcare provider before starting any new supplement. This ensures it aligns with individual health needs and fitness goals.
Introduction To Nitric Boost Ultra
Nitric Boost Ultra is a popular supplement. It promises to improve your health. People use it for better workouts. It helps with muscle growth and energy. Many athletes use it daily. They claim it works well for them. This product aims to increase nitric oxide levels. High nitric oxide can enhance blood flow. Good blood flow means better performance. Visit official Website - Click Now

Secret Recipe - Watch now
How Nitric Boost Ultra Works
Nitric Boost Ultra helps your body make nitric oxide. Nitric oxide is a natural gas. It helps blood vessels open wider. This makes blood flow better.
The body uses amino acids to make nitric oxide. These acids come from food. Nitric Boost Ultra gives you more of these acids. This helps your body make more nitric oxide.
Research shows that nitric oxide helps the heart. It also helps with exercise. More nitric oxide means more oxygen in your muscles. This helps you work out longer. It also helps you recover faster.
Scientists have studied nitric oxide for years. They found it helps with blood pressure. It also helps with energy levels. Many people take supplements for these reasons.
Benefits Of Nitric Boost Ultra
Nitric Boost Ultra helps increase blood flow. This leads to better performance in physical activities. Athletes find it useful for boosting endurance. It also helps in faster recovery after workouts. Enhanced stamina is another benefit users report. Improved oxygen delivery to muscles is crucial. This supplement aids in achieving that.
Better blood circulation means a healthier heart. Nitric Boost Ultra supports cardiovascular health. It helps in maintaining normal blood pressure. Users have reported feeling more energetic. Better circulation also aids in improving brain function. This can lead to better focus and clarity.
User Reviews And Testimonials
Many users love Nitric Boost Ultra. They feel more energetic and focused. Some users have shared that they notice improved stamina during workouts. Others appreciate the quick results they see. People also praise the natural ingredients in the product. They feel it is a safe choice. The easy-to-use format is another plus point. Users find it simple to take the supplement daily. Many reviewers say they would recommend it to friends.
Some users experience mild side effects. These can include headaches or nausea. A few feel the product is a bit expensive. Others think the results are slow to appear. Some users are not happy with the taste. There are also complaints about delayed shipping. A few people feel the packaging could be better. Despite these issues, many still find the product worth trying.
Comparing Nitric Boost Ultra To Competitors
Many brands offer nitric oxide supplements. Some common alternatives include NitroBlast and NO2 Max. Each brand has unique features and ingredients. NitroBlast focuses on rapid absorption. NO2 Max emphasizes muscle endurance.
Nitric Boost Ultra stands out due to its natural ingredients. It also boasts a proven track record in user reviews. Most users report enhanced energy levels and improved workout performance. Competitors often lack such comprehensive benefits.
Nitric Boost Ultra has several unique selling points. Firstly, it uses natural and safe ingredients. Secondly, it offers fast results according to user reviews. Thirdly, many users report improved stamina and better recovery. These features make it a popular choice among fitness enthusiasts.
Potential Side Effects
Nitric Boost Ultra may cause mild side effects like headaches, dizziness, or stomach discomfort. Users should consult a doctor before starting.
Mild Reactions
Some users report mild reactions like headaches and dizziness. Others feel slight nausea after taking the supplement. Stomach discomfort may also occur. These effects usually go away quickly. Drinking water can help reduce these symptoms. It is important to follow the dosage instructions. Overuse can increase the risk of mild side effects.
Severe Reactions
Severe reactions are rare but possible. Some people may experience chest pain. Shortness of breath is another serious symptom. Allergic reactions like rash and itching can occur. Swelling of the face or throat is a medical emergency. Stop using the product if you notice severe side effects. Contact a healthcare professional immediately.
Usage And Dosage
The recommended dosage for Nitric Boost Ultra is two capsules per day. Take one capsule in the morning and one in the evening. Do not exceed the recommended amount. Always drink plenty of water with each capsule.
For optimal results, take Nitric Boost Ultra with a meal. Consistent use is key to seeing benefits. Store the bottle in a cool, dry place. Keep it away from direct sunlight. Avoid taking it on an empty stomach to prevent any discomfort.
Where To Buy Nitric Boost Ultra
Official retailers often provide the best prices and genuine products. Many buyers trust these sources for their purchases. The manufacturer’s website is a popular option. You can also find it in authorized health stores. Official retailers may offer special discounts and promotions. Always check for authenticity seals on the packaging.
Online platforms like Amazon and eBay offer Nitric Boost Ultra. These platforms provide customer reviews and ratings. It’s essential to read reviews before buying. Some platforms offer free shipping and easy returns. Be cautious of counterfeit products. Always buy from trusted sellers.
Final Verdict
Nitric Boost Ultra reviews highlight its potential benefits for enhanced athletic performance and increased energy. Users report noticeable improvements in stamina and workout efficiency.
Overall Effectiveness
Nitric Boost Ultra shows promising results. Many users report increased energy levels. Some notice improved endurance during workouts. A few find it helps with muscle recovery. Others mention better overall stamina.
Value For Money
The product offers good value for its price. It is affordable compared to similar supplements. Users feel they get quality results. Many believe it is worth the investment. Some find the benefits outweigh the costs.
Frequently Asked Questions
What Is Nitric Boost Ultra?
Nitric Boost Ultra is a dietary supplement designed to enhance nitric oxide levels. It aims to improve blood flow, energy, and workout performance.
How Does Nitric Boost Ultra Work?
Nitric Boost Ultra works by increasing nitric oxide production in the body. This helps improve blood circulation and enhances muscle oxygenation.
Are Nitric Boost Ultra Reviews Positive?
Yes, many users report positive experiences with Nitric Boost Ultra. They mention improved energy, better workouts, and faster recovery times.
What Are The Side Effects Of Nitric Boost Ultra?
Most users report minimal to no side effects. However, some may experience mild headaches or digestive issues.
Conclusion
Nitric Boost Ultra has received positive reviews for enhancing energy and performance. Many users report noticeable improvements. It's essential to consult a healthcare professional before starting any supplement. Overall, Nitric Boost Ultra may offer benefits for those seeking to boost their workout results.

 

[nurjahan678]

Hi,

Nitric Boost supplement is designed to improve a man's intimate performance by raising his levels of nitric oxide, which increases vitality and blood flow. It usually comes in powder or capsule form and contains ingredients like Ginkgo Biloba, Horny Goat Weed, Dong Quai, and Beetroot Powder. These ingredients improve circulation and energy levels, which in turn increases confidence, endurance, and performance. The goal of the supplement is to offer a natural remedy for enhancing personal relationships and general wellbeing.

How Does Nitric Boost Works?

1. Boosts Nitric Oxide Production: Nitric Oxide helps relax and widen blood vessels, improving blood flow to intimate areas.
2. Enhances Blood Flow: Better circulation leads to increased sensitivity and performance.
3. Supports Energy and Stamina: Ingredients in Nitric Boost are intended to improve overall energy levels and vitality.

Benefits:

• Increased Confidence: Improved intimate performance can boost self-esteem.
• Enhanced Performance: Better blood flow can lead to more satisfying experiences.
• Increased Energy: More energy and stamina for both intimate and daily activities.

Usage:

• Dosage: Generally recommended to take one serving daily, though specifics may vary by product.
• Forms: Available in powder, capsule, or tablet form.

Secret Recipe - Watch now

Is There a Money-Back Guarantee?

Yes, Nitric Boost often comes with a 180-day money-back guarantee. This allows you to try the supplement risk-free, and if you’re not satisfied with the results, you can return it within the guarantee period for a full refund. This policy provides extra confidence when considering the purchase.

But, I still recommend you read more reviews before you try it. It gives you more assurance.

 

[nurjahan678]

What is Nitric Boost Beoordelingen?
Regrettably, I do not have adequate background information to answer a specific query apropos Nitric Boost Beoordelingen. By browsing the net it appears to mean some form of a product or perhaps a service, however, without more specification, I cannot tell for sure what it is or rate it or give reviews about it. It will help me to help you if you surrender more background information about what you are looking for as per your question above. Kindly inform me whether you would like me to elaborate the following issues about Nitric Boost Beoordelingen;

 

[nurjahan678]

Nitric oxide (NO) is an essential component of the human body, involved in blood vessel dilation, stimulation of hormone release, signaling and regulation of neurotransmission. Nitric oxide is synthesized by nitric-oxide-synthase-dependent and -independent pathways. Nitric oxide supplementation improves cardiac health, enhances performance during exercise, reduces high blood pressure during pregnancy, reduces erectile dysfunction and improves healing processes and respiratory response. Nitric-oxide-associated benefits are mostly apparent in untrained or moderately trained individuals. L-arginine and L-citrulline supplementation contributes to nitric oxide levels because L-arginine is directly involved in NO synthesis, whereas L-citrulline acts as an L-arginine precursor that is further converted to NO by a reaction catalyzed by NO synthase. L-arginine supplements increase respiratory response and enhance performance during exercise, while L-citrulline with malate and other molecules increase working capacity. Various studies involving beetroot juice have reported a significant increase in plasma nitrite levels, regarded as markers of NO, after intake of beetroot juice. Although NO supplementation may have mild to moderate side-effects, using smaller or divided doses could avoid some of these side-effects. Since nitric oxide supplementation may worsen certain health conditions and may interfere with certain medicines, it should only be taken under medical supervision.

Keywords: Nitric oxide supplementation, Nitric oxide synthesis, L-arginine supplementation, L- citrulline supplementation, Dietary supplements

Citation​

How to cite this article: Kiani AK, Bonetti G, Medori MC, Caruso P, Manganotti P, Fioretti F, Nodari S, Connelly ST, Bertelli M. Dietary supplements for improving nitric-oxide synthesis. J Prev Med Hyg 2022;63(suppl.3):E239-E245. https://doi.org/10.15167/2421-4248/jpmh2022.63.2S3.2766

Nitric oxide​

Nitric oxide or nitrogen monoxide (NO) is a component of the human body that may cause dilation of blood vessels and release of hormones such as human growth hormone (GH) and insulin [1]. Shortly after the role of NO as a signaling molecule was established, it emerged that particular nitric oxide synthases (NOS) catalyze the intricate enzyme reactions that lead to synthesis of NO from the substrates L-arginine and molecular oxygen. An alternative pathway of NO synthesis, known as NOS-independent, was subsequently discovered: it is based on simple reduction of nitrate and nitrite, major NO oxidation products. Nitric oxide acts as a mediator and regulates significant non-cholinergic and noradrenergic neurotransmission functions involving memory, learning, neuroprotection and synaptic plasticity [2].

Although nitric oxide supplementation has been used for decades, little scientific evidence is available to support its health benefits [1]. The composition of NO-stimulating supplements is mostly a cocktail of amino acids, creatine, minerals, carbohydrates, vitamins, and so forth. Studies have also shown that components like creatine, amino acids and carbohydrates may have ergogenic effects among themselves [2, 3].

Many studies have used NO-donors and other components like malate, aspartate and glutamate to enhance NO-donor bioavailability [2]. Benefits associated with NO-donors have been reported in moderately trained individuals, whereas recent scientific data indicates that well-trained athletes benefit less from NO supplements. Hence it appears that the training status of an individual is a significant factor for dietary NO-donor effectiveness. One logical explanation of the association of exercise with the effectiveness of NO supplementation may be due to the positive effect of physical exercise on the regulation of NO metabolism. Although short-term physical training promptly increases the bioactivity of NO, if training is continued, the short-term functional changes are followed by NO-dependent structural changes that lead to arterial re-modelling and the structural normalization of shear [4].

Two of the most prevalent NO supplements are L-arginine and L-citrulline. Scientists have conducted various clinical trials on the effectiveness and side-effects of NO supplements [5].

L-arginine​

L-arginine is a metabolically versatile amino acid involved in building proteins and in the synthesis of NO. It is found naturally in dairy products, red meat, fish and poultry. Commercial manufacturers produce it as a pill, cream or powder. According to a recently published article, a normal person typically consumes almost 5 g L-arginine per day without NO supplementation. The human body converts consumed L-arginine into NO for different body functions [6].

Different research studies have reported an increase in exercise performance after consumption of supplements containing L-arginine and other components by moderately trained and untrained subjects. For example, in their recent study Bailey et al. reported that 6 g/day L-arginine for 3 days with vitamins and other amino acids led to a reduction in VO2 (rate of oxygen consumption) in low to moderate exercise sessions and an extension of exhaustion time (L-arginine: 707-232 seconds; placebo: 562-145 seconds) during the cycling incremental exercise test [7].

In another study, high-dose L-arginine supplementation (14.2 g/day) was given to females for almost 6 months. At the end of the period, a significant increase in relative maximum power (power/kg), measured as peak jump power in the countermovement jump test, was observed [8]. Certain male studies show that L-arginine supplements may increase respiratory response. Likewise Koppo et al. showed significantly higher speed in phase II of the VO2 (rate of oxygen consumption) during moderate intensity endurance cycling after 6 g/day L-arginine supplementation for 14 days [8, 9].

Chen et al. found that L-arginine supplementation 5.2 g/day for 21 days with L-citrulline and antioxidants increased the power output of elderly males by almost 21% during the incremental cycle ergometer exhaustion test [10]. These results have been associated with an increase in the gas exchange threshold after L-arginine supplementation. Researchers have also suggested that attenuation of metabolic products like potassium, lactate and ammonia may be caused by increased clearance from the circulation due to NO synthesis and increased blood flow [10, 11].

Several other studies have also established the benefits of L-arginine supplementation in strength and power performance among moderately-trained individuals. Campbell et al. reported that L-arginine supplements (6 g/day for 56 days) with a-keto-glutarate significantly increased the value of the one-repetition-maximum bench press test and peak power in a 30-second Wingate anaerobic test [12]. Stevens et al. and Buford & Koch, measured the acute dose of L-arginine, namely 6 g L-arginine as a-keto-isocaproic supplements, that increases the work sustained in continuous isokinetic eccentric/concentric knee extension repeats and mean power performance during the Wingate anaerobic test for 10 seconds, respectively [13, 14].

Bailey et al. [24] analysed plasma levels of nitrite and reported a significant increase after L-arginine supplements. In animal models, L-arginine-supplemented diets caused a 1-2% increase in intramuscular concentrations of creatine phosphate, which may lead to increased response in anaerobic exercise [24]. These results support Buford and Koch’s finding of increased performance during recurrent bouts of anaerobic cycling after taking glycine-arginine-a-ketoisocaproic acid supplements [13].

L-citrulline​

L-citrulline is a non-essential amino acid found naturally in nuts, meat, watermelon and legumes [15]. It is manufactured commercially as a powder or pill. In the body, L-citrulline is synthesized by conversion of L-arginine to NO in a NOS-catalyzed reaction. In healthy populations, normal plasma concentrations of L-citrulline are reported to be almost 25 mmol/L, although lower values were recently measured (10-15 mmol/L) in professional cyclists [16, 17].

In recent years, dietary interest in L-citrulline has arisen due to its significance as a L-arginine precursor. Interestingly, unlike L-arginine, L-citrulline bypasses hepatic metabolism and is not catalyzed by arginase enzymes. Physiologists have therefore established that systemic administration of L-citrulline alone could be an efficient way to raise extracellular levels of L-arginine. Enterocytes take up dietary L-citrulline and release it into the portal circulation, bypassing metabolization by periportal hepatocytes and transporting it to the kidneys where almost 80% is catabolized to L-arginine by proximal tubule cells [18-20].

Various studies have analysed the effects of L-citrulline in combination with malate, an intermediate of the tricarboxylic acid cycle. Initial studies calculated adenosine triphosphate (ATP) production rates during finger flexion exercise by 31-phosphorus magnetic resonance spectroscopy. The results showed that taking 6 g/day L-citrulline with malate for almost 16 days led to a significant increase (almost 34%) in the oxidative production rate of ATP during exercise and a 20% increase in the phosphocreatine recovery rate after exercise [21].

Lately a research group conducted two studies that showed increased plasma levels of NO metabolites in well-trained athletes at the end of a cycling competition; 2 hours before the race, the athletes had taken a single 6-g dose of L-citrulline with malate [16]. An increase in the availability of plasma arginine has also been linked to availability of substrate for NO synthesis and to the activity of polymorphonuclear neutrophils. Another current study by Perez-Guisado and Jakeman confirmed that a single 8-g dose L-citrulline with malate increased working capacity by almost 19%, as measured by the number of repetitions completed until exhaustion in a bench-press fitness test at 80% of one-repetition-maximum [16, 22].

Nitric oxide synthesis by the NO-synthase-dependent pathway​

The nitric oxide synthase (NOS)-dependent pathway of NO synthesis involves the amino acid L-arginine which participates in a reaction catalyzed by particular NOS enzymes. Extracellular L-arginine is rapidly taken up by endothelial cells in the presence of molecular oxygen and NADP (nicotinamide adenosine dinucleotide phosphate), and L-arginine is then oxidized to NO [23]. This complex reaction is catalyzed by NOS enzymes containing an L-arginine binding site. Three nitric oxide synthase isoforms have so far been recognized, including type I or neuronal NOS (nNOS), type II or inducible NOS (iNOS) and type III or endothelial NOS (eNOS). Both iNOS and eNOS are constitutive enzymes regulated by intracellular calcium/calmodulin, although expression of nNOS may be induced at gene transcription level by aging processes, muscle activity, macrophages and other tissues responding to inflammatory mediators, independent of Ca2+ levels. L-citrulline may also be considered an alternative NO-donor, because it may bring about an increase in L-arginine levels [24-26].

Nitric oxide synthesis by the NO-synthase-independent pathway​

In the 1990s, two distinct research groups discovered a NOS-independent pathway for NO synthesis [27, 28]. This alternative pathway used nitrate and nitrite as its main precursors. The NOS-dependent pathway is oxygen dependent, whereas the NOS independent nitrate/nitrite pathway of NO synthesis is activated gradually as oxygen tension falls [29].

Circulating nitrate has a half-life of almost 5 hours and is distributed to different tissues. Although the full mechanism is not yet completely defined, various studies have revealed that nitrate circulating in plasma is actively absorbed by salivary glands where its concentration is enhanced in saliva (10 to 20 times higher than in blood) [30]. In the oral cavity, certain facultative anaerobic bacteria that live on the tongue surface reduce this nitrate to nitrite by means of nitrate reductase. Hence in the absence of oxygen, these anaerobic bacteria utilize nitrate as an alternative electron-acceptor to produce ATP. After swallowing, half the nitrite present in saliva is transferred to the acidic stomach environment and is metabolized to NO, while the other half remains intact and is reabsorbed to increase circulating concentrations of nitrite in plasma. Under suitable physiological conditions, this nitrite may be converted into NO and other biologically active nitrogen oxides in the tissues and blood. These findings establish the presence of a completely reverse/alternative pathway (nitrate–nitrite–NO) in mammals [28, 31].

Nitrate supplementation​

The alternative NO synthesis pathway has also been well studied with reference to exercise physiology. Nitrate and nitrite modulate mitochondrial respiration through NO synthesis. Two recent studies by the same research group showed that plasma NO metabolites like nitrate and nitrite increased significantly after nitrate treatment. The efficiency of human mitochondria, assessed in vitro by oxygen consumption per molecule of ATP produced (phosphate/oxygen ratio), was significantly enhanced with respect to a placebo group after intake of 0.1 mmol/kg sodium nitrate for 3 days [32-34].

Interestingly, studies involving beetroot juice have also reported a significant increase in plasma nitrite levels (regarded as markers of NO) after intake of beetroot juice. Larsen et al. reported it as an alternative metabolic pathway for mitochondrial respiration which might explain the decrease in oxygen demand during exercise after ingestion of nitrate-rich food [34].

In five other studies by the same research group, nitrate supplementation was taken as beetroot juice and its effects on human performance were assessed. In one of these studies, Bailey et al. reported a significant increase in oxygen uptake kinetics (VO2) after dietary supplementation with nitrate-rich beetroot juice (500 ml/day for 6 days) [35].

Beetroot juice supplements brought about a 19% decrease in pulmonary response amplitude during low to moderate-intensity exercise, such as cycle ergometer. Beetroot supplementation also caused a 23% decrease with respect to a placebo group in the slow component of VO2 and a 19% extension of exhaustion time in the incremental cycle ergometer test [35]. The effect of nitrate provided by beetroot juice supplementation was also observed to be faster and acute intake affected cardiovascular response within a few hours [36]. Vanhatalo et al. validated this effect of beetroot juice supplementation. They gave a single dose of beetroot juice (500 mL beetroot juice equivalent to 434 mg sodium nitrate) to subjects 2.5 hours prior to a cycle-based ergometer test involving two moderate work-loads with 90% gas exchange threshold, followed by the ramp test [7]. In another study, Lansley et al. used the same dose of beetroot juice 2.5 hours prior to exercise and observed significant improvement in mean completion time (2.8%) and average power output (5%) during 4-16.1 km of cycle ergometer time trials, with respect to the placebo group [37].

Glycine propionyl-L-carnitine​

Glycine propionyl-L-carnitine (GPLC) is a carnitine propionyl ester with an extra glycine. It is used as a dietary supplement to increase blood levels of nitrate/nitrite which are surrogate markers of NO. It improves metabolism of NO in two ways: 1) as reported in certain animal studies, the protective action of GPLC is due to its antioxidant properties which may prevent peroxidative damage of vessels. On this basis, other researchers proposed that reduced release of reactive oxygen species could be associated with lower breakdown of NO; 2) a substantial increase in expression of the eNOS gene was observed in culture medium of human endothelial cells after incubation with carnitine. Hence, researchers suggested that GPLC could also stimulate NO synthesis through eNOS gene expression [38-42].

A number of recent studies have analysed the effect of GPLC as a NO donor in exercise and sport with different conclusions. Bloomer et al. reported a substantial increase in the plasma metabolites of NO, like nitrate and nitrite, in active male athletes after supplementation with GPLC (4.5 g/day for 4 weeks) [42]. Another study by the same research group further validated these results. [43] Results obtained by Jacobs et al. revealed that a single dose of GPLC (4.5 g) 90 minutes prior to a performance test, including 5-10-seconds of Wingate sprints on a cycle ergometer separated by active recovery periods of one minute, caused a significant increase in peak power (5.2%) and a decrease in power decrement (5.2%) in sprints, with respect to the placebo group [44].

2-(Nitroxy) ethyl 2-amino-3- methylbutanoate​

The 2-(nitroxy) ethyl 2-amino-3-methylbutanoate molecule was recently recognized to increase the delivery of NO in the human body and is considered to be more effective and efficient than other traditional NO donors. A study of the effects of 2-(nitroxy) ethyl 2-amino-3-methylbutanoate on plasma NO markers quantified nitrate/nitrite levels among moderately resistance-trained males. Several other studies also suggest that NO supplementation increases blood flow in the human body, enhancing individual performance in exercise and sport, and promoting cardiac health, healing and other potential benefits [45].

Benefits​

Various researchers believe that NO causes body relaxation and widens or dilates the blood vessels [6].

Improving heart health​

Nitric oxide supplementation has many beneficial and boosting effects on the heart. These effects include reduction of blood pressure and arterial stiffness and improvement of blood flow in the carotid artery. However, most of these studies are based on animal models. Further human studies are required to validate these effects of nitric oxide supplementation on the human heart [5].

Enhancing exercise and recovery​

The significance of NO is quite prominent in exercise physiology and NO supplementation is considered an ergogenic aid. Nitric oxide proves to be a significant blood flow and mitochondrial respiration modulator in physical exercise [46]. Various researchers have suggested that nitric oxide supplementation could increase oxygen delivery to the muscles. This could enhance athletic performance and reduce soreness after workouts [2]. Moreover, genetic variants in several genes, among which nitric oxide synthase 3, the enzyme responsible for NO synthesis, are correlated to endurance performance and trainability [47-49].

Several studies published in the journal Sports Medicine suggest that NO supplements may increase exercise tolerance. However, this effect is more prominent in subjects who exercise at a moderate rate and not regularly. The studies were mostly conducted on young males and therefore do not predict or offer insights into the effect of NO supplementation on older subjects or women [2].

It is also proposed that the increase in the blood flow caused by NO synthesis may improve the recovery and healing of activated tissues. Most commercial NO supplements claim to provide all these benefits and to increase the performance of support related individuals [45].

Reducing erectile dysfunction​

As NO supplements increases blood flow, they have been studied for erectile dysfunction. Some published studies show that NO supplementation may reduce erectile dysfunction in mild to moderate cases [50].

Reducing high blood pressure in pregnancy​

Preeclampsia, also known as gestational hypertension, may endanger both mother and fetus. In 2005, a study reported that pregnant women who took L-arginine supplements for prolonged periods had lower blood pressure than those who did not. Although more studies are required to understand these findings, it is a promising result [51].

Other reported benefits​

There are some further benefits of nitric oxide supplementation. Research studies have reported that nitric oxide supplementation increases weight loss [52]. Improvement in lung function was also observed after nitric oxide supplementation in cystic fibrosis patients undergoing treatment for altitude sickness. Studies conducted on male subjects report remarkable enhancement of respiratory response after L-arginine supplementation. Koppo et al. [12] observed significant enhancement of speed during phase II of pulmonary oxygen consumption (VO2) at the start of moderately intense endurance exercise after L-arginine supplements (6 g/day for 14 days) [9]. Better recovery was observed after major injury or trauma with nitric oxide supplementation, which also played role in prevention of the common cold. Nitric oxide supplementation is suggested to reduce the side-effects of memory loss. Other studies propose that nitric oxide supplementation could help the healing of diabetic foot ulcers [53].

However, most of these benefits lack scientific support and are generally not based on research. The claims should be properly investigated before accepting or rejecting them.

Side-effects​

Although dietary supplements with L-arginine and L-citrulline are considered safe, they may nevertheless have mild to moderate side-effects, including gastrointestinal disturbances like vomiting, nausea, bloating, diarrhea, stomach pain, as well as headache, heartburn and palpitations [54]. Tolerance of these amino acids differs greatly between individuals and higher doses (>9 g/day) may increase the risk of gastrointestinal distress. It is suggested that smaller or divided doses may cause fewer adverse effects [55]. Existing or prior prosecretory or proabsorptive intestinal states may increase susceptibility. A secretory intestinal state combined with the extra stimulation of higher doses (> 9 g/day) of L-arginine, L-citrulline or both may overwhelm the capacity of the colon to re-absorb [54].

Nitric oxide supplementation could have a higher risk of side-effects in persons with certain health conditions. Such health conditions include cirrhosis, guanidinoacetate methyltransferase deficiency and low blood pressure. Individuals suffering from liver scarring or cirrhosis should be cautious about taking nitric oxide supplements as they could worsen liver function [556]. Guanidinoacetate methyltransferase deficiency (GAMT) is a genetic condition associated with lack arginine to creatine converting enzyme. People with GAMT should therefore not take NO supplements [57]. Persons with low blood pressure should stop nitric oxide supplementation before undergoing any surgery. Medical practitioners have expressed concern that nitric oxide supplementation could aggravate other health conditions including kidney disease, heart conditions and viral infections such as herpes [51, 54].

In 2006, a study reported that individuals taking L-arginine after suffering a heart attack were at high risk of gastrointestinal motility, repeated heart attack and hospitalization than heart patients who did not [58].

Nitric oxide supplements may interfere with certain medications, such as blood pressure and diabetes medication. Before taking nitric oxide supplements, individuals should consult their health practitioners to avoid side-effects or interference with their medication [51, 59].

Another interesting fact is that in most research assessing the effect of NO supplementation on athletic performance and during sport or exercise, the amount of nitric oxide obtained from supplements could easily have been obtained from the natural food sources like green leafy vegetables and beetroot juice. Obtaining nitric oxide from natural food sources is a better option for avoiding certain side-effects [2].

Conclusions​

Nitric oxide is a physiological compound of the human body that dilates blood vessels, stimulates hormone release, regulates neurotransmission and acts as a signaling molecule. Nitric oxide is synthesized by NOS-dependent and -independent pathways. Nitric oxide supplementation improves cardiac health, enhances performance during exercise, improves healing, reduces erectile dysfunction, reduces high blood pressure during pregnancy and improves respiratory response.

The benefits associated with NO have mostly been obtained in moderately trained individuals. Two prevalent NO supplements are L-arginine and L-citrulline. L-arginine is involved in NO synthesis. L-arginine supplements increase respiratory response and enhance performance during exercise. L-citrulline is a L-arginine precursor that is converted into NO by a reaction catalyzed by NOS. L-citrulline combined with malate and other molecules increase working capacity. Many studies on beetroot juice report a significant increase in plasma nitrite levels, a NO marker, after intake of beetroot juice. Similarly, glycine propionyl-L-carnitine and 2-(nitroxy) ethyl 2-amino-3-methylbutanoate are dietary supplements that act as nitric oxide donors, enhance nitric oxide synthesis and may also stimulate NO synthesis through expression of the eNOS gene.

Nitric oxide supplementation may have mild to moderate side-effects including gastrointestinal disturbances like vomiting, nausea, bloating, diarrhea, stomach pain, as well as headache, heartburn and palpitations. To avoid these side-effects, smaller or divided doses of these supplements are suggested. Nitric oxide supplements should not be taken by persons with certain health conditions and may interfere with medication. They should therefore only be taken under medical supervision.

Acknowledgements​

This research was funded by the Provincia Autonoma di Bolzano in the framework of LP 15/2020 (dgp 3174/2021).

Conflicts of interest statement​

Authors declare no conflict of interest.

Author's contributions​

MB: study conception, editing and critical revision of the manuscript; AKK, MCM, PC, PM, FF, SN, STC: literature search, editing and critical revision of the manuscript. All authors have read and approved the final manuscript.

 

[nurjahan678]

Order Now to Get Nitric Boost Directly From the Official Website!​

References​

• [1].Jones AM, Vanhatalo A, Seals DR, Rossman MJ, Piknova B, Jonvik KL. Dietary nitrate and nitric oxide metabolism: mouth, circulation, skeletal muscle, and exercise performance. Med Sci Sports Exerc 2021;53:280-94. https://doi.org/10.1249/MSS.0000000000002470 10.1249/MSS.0000000000002470 [DOI] [PubMed] [Google Scholar]
• [2].Bescos R, Sureda A, Tur JA, Pons A. The effect of nitric-oxide-related supplements on human performance. Sports Med 2012;42:99-117. https://doi.org/10.2165/11596860-000000000-00000 10.2165/11596860-000000000-00000 [DOI] [PubMed] [Google Scholar]
• [3].Tipton KD, Ferrando AA. Improving muscle mass: response of muscle metabolism to exercise, nutrition and anabolic agents. Essays Biochem 2008;44:85-98. https://doi.org/10.1042/BSE0440085 10.1042/BSE0440085 [DOI] [PubMed] [Google Scholar]
• [4].Maiorana A, O’Driscoll G, Taylor R, Green D. Exercise and the nitric oxide vasodilator system. Sports Med 2003;33:1013-35. https://doi.org/10.2165/00007256-200333140-00001 10.2165/00007256-200333140-00001 [DOI] [PubMed] [Google Scholar]
• [5].Morita M, Hayashi T, Ochiai M, Maeda M, Yamaguchi T, Ina K, Kuzuya M. Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability. Biochem Biophys Res Commun 2014;454:53-7. https://doi.org/10.1016/j.bbrc.2014.10.029 10.1016/j.bbrc.2014.10.029 [DOI] [PubMed] [Google Scholar]
• [6].McNeal CJ, Meininger CJ, Reddy D, Wilborn CD, Wu G. Safety and effectiveness of arginine in adults. J Nutr 2016;146:2587S-2593S. https://doi/org.10.3945/jn.116.234740 10.3945/jn.116.234740 [DOI] [PubMed] [Google Scholar]
• [7].Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, Benjamin N, Winyard PG, Jones AM. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol 2010;299:R1121-31. https://doi/org.10.1152/ajpregu.00206.2010 10.1152/ajpregu.00206.2010 [DOI] [PubMed] [Google Scholar]
• [8].Fricke O, Baecker N, Heer M, Tutlewski B, Schoenau E. The effect of L-arginine administration on muscle force and power in postmenopausal women. Clin Physiol Funct Imaging 2008;28:307-11. https://doi.org/10.1111/j.1475-097X.2008.00809.x 10.1111/j.1475-097X.2008.00809.x [DOI] [PubMed] [Google Scholar]
• [9].Koppo K, Taes YE, Pottier A, Boone J, Bouckaert J, Derave W. Dietary arginine supplementation speeds pulmonary VO2 kinetics during cycle exercise. Med Sci Sports Exerc 2009;41:1626-32.https://doi.org/10.1249/MSS.0b013e31819d81b6 10.1249/MSS.0b013e31819d81b6 [DOI] [PubMed] [Google Scholar]
• [10].Chen S, Kim W, Henning SM, Carpenter CL, Li Z. Arginine and antioxidant supplement on performance in elderly male cyclists: a randomized controlled trial. J Int Soc Sports Nutr 2010;7:13.https://doi.org/10.1186/1550-2783-7-13 10.1186/1550-2783-7-13 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [11].Camic CL, Housh TJ, Mielke M, Zuniga JM, Hendrix CR, Johnson GO, Schmidt RJ, Housh DJ. The effects of 4 weeks of an arginine-based supplement on the gas exchange threshold and peak oxygen uptake. Appl Physiol Nutr Metab 2010;35:286-93. https://doi.org/10.1139/H10-019 10.1139/H10-019 [DOI] [PubMed] [Google Scholar]
• [12].Campbell B, Roberts M, Kerksick C, Wilborn C, Marcello B, Taylor L, Nassar E, Leutholtz B, Bowden R, Rasmussen C, Greenwood M, Kreider R. Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men. Nutrition 2006;22:872-81. https://doi.org/10.1016/j.nut.2006.06.003 10.1016/j.nut.2006.06.003 [DOI] [PubMed] [Google Scholar]
• [13].Buford BN, Koch AJ. Glycine-arginine-alpha-ketoisocaproic acid improves performance of repeated cycling sprints. Med Sci Sports Exerc 2004;36:583-7. https://doi.org/10.1249/01.mss.0000122075.14060.c4 10.1249/01.mss.0000122075.14060.c4 [DOI] [PubMed] [Google Scholar]
• [14].Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High-intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc 2000;32:2102-8. https://doi.org/10.1097/00005768-200012000-00021 10.1097/00005768-200012000-00021 [DOI] [PubMed] [Google Scholar]
• [15].Bailey SJ, Blackwell JR, Lord T, Vanhatalo A, Winyard PG, Jones AM. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol 2015;119:385-95. https://doi.org/10.1152/japplphysiol.00192.2014 10.1152/japplphysiol.00192.2014 [DOI] [PubMed] [Google Scholar]
• [16].Sureda A, Cordova A, Ferrer MD, Tauler P, Perez G, Tur JA, Pons A. Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise. Free Radic Res 2009;43:828-35. https://doi.org/10.1080/10715760903071664 10.1080/10715760903071664 [DOI] [PubMed] [Google Scholar]
• [17].Mehta S, Stewart DJ, Levy RD. The hypotensive effect of L-arginine is associated with increased expired nitric oxide in humans. Chest 1996;109:1550-5. https://doi.org/10.1378/chest.109.6.1550 10.1378/chest.109.6.1550 [DOI] [PubMed] [Google Scholar]
• [18].Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. https://doi.org/10.1111/j.1527-3466.2006.00275.x 10.1111/j.1527-3466.2006.00275.x [DOI] [PubMed] [Google Scholar]
• [19].Rouge C, Des Robert C, Robins A, Le Bacquer O, Volteau C, De La Cochetiere MF, Darmaun D. Manipulation of citrulline availability in humans. Am J Physiol Gastrointest Liver Physiol 2007;293:G1061-7. https://doi.org/10.1152/ajpgi.00289.2007 10.1152/ajpgi.00289.2007 [DOI] [PubMed] [Google Scholar]
• [20].van de Poll MC, Soeters PB, Deutz NE, Fearon KC, Dejong CH. Renal metabolism of amino acids: its role in interorgan amino acid exchange. Am J Clin Nutr 2004;79:185-97. https://doi.org/10.1093/ajcn/79.2.185 10.1093/ajcn/79.2.185 [DOI] [PubMed] [Google Scholar]
• [21].Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med 2002;282-9. https://doi.org/10.1136/bjsm.36.4.282 10.1136/bjsm.36.4.282 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [22].Perez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. https://doi.org/10.1519/JSC.0b013e3181cb28e0 10.1519/JSC.0b013e3181cb28e0 [DOI] [PubMed] [Google Scholar]
• [23].Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002-12. https://doi.org/10.1056/NEJM199312303292706 10.1056/NEJM199312303292706 [DOI] [PubMed] [Google Scholar]
• [24].Balon TW, Nadler JL. Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol 1997;82:359-63. https://doi.org/10.1152/jappl.1997.82.1.359 10.1152/jappl.1997.82.1.359 [DOI] [PubMed] [Google Scholar]
• [25].Capanni C, Squarzoni S, Petrini S, Villanova M, Muscari C, Maraldi NM, Guarnieri C, Caldarera CM. Increase of neuronal nitric oxide synthase in rat skeletal muscle during ageing. Biochem Biophys Res Commun 1998;245:216-9. https://doi.org/10.1006/bbrc.1998.8404 10.1006/bbrc.1998.8404 [DOI] [PubMed] [Google Scholar]
• [26].Shen W, Zhang X, Zhao G, Wolin MS, Sessa W, Hintze TH. Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise. Med Sci Sports Exerc 1995;27:1125-34. [PubMed] [Google Scholar]
• [27].Benjamin N, O’Driscoll F, Dougall H, Duncan C, Smith L, Golden M, McKenzie H. Stomach NO synthesis. Nature 1994;368:502. https://doi.org/10.1038/368502a0 10.1038/368502a0 [DOI] [PubMed] [Google Scholar]
• [28].Lundberg JO, Weitzberg E, Lundberg JM, Alving K. Intragastric nitric oxide production in humans: measurements in expelled air. Gut 1994;35:1543-6. https://doi.org/10.1136/gut.35.11.1543 10.1136/gut.35.11.1543 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [29].Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 2008;7:156-67. https://doi.org/10.1038/nrd2466 10.1038/nrd2466 [DOI] [PubMed] [Google Scholar]
• [30].Tannenbaum SR, Weisman M, Fett D. The effect of nitrate intake on nitrite formation in human saliva. Food Cosmet Toxicol 1976;14:549-52. https://doi.org/10.1016/s0015-6264(76)80006-5 10.1016/s0015-6264(76)80006-5 [DOI] [PubMed] [Google Scholar]
• [31].Lundberg JO, Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med 2004;37:395-400. https://doi.org/10.1016/j.freeradbiomed.2004.04.027 10.1016/j.freeradbiomed.2004.04.027 [DOI] [PubMed] [Google Scholar]
• [32].Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol 2007;191:59-66. https://doi.org/10.1111/j.1748-1716.2007.01713.x 10.1111/j.1748-1716.2007.01713.x [DOI] [PubMed] [Google Scholar]
• [33].Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med 2010;48:342-7. https://doi.org/10.1016/j.freeradbiomed.2009.11.006 10.1016/j.freeradbiomed.2009.11.006 [DOI] [PubMed] [Google Scholar]
• [34].Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab 2011;13:149-59. https://doi.org/10.1016/j.cmet.2011.01.004 10.1016/j.cmet.2011.01.004 [DOI] [PubMed] [Google Scholar]
• [35].Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol 2010;109:135-48. https://doi.org/10.1152/japplphysiol.00046.2010 10.1152/japplphysiol.00046.2010 [DOI] [PubMed] [Google Scholar]
• [36].Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension 2008;51:784-90. https://doi.org/10.1161/HYPERTENSIONAHA.107.103523 10.1161/HYPERTENSIONAHA.107.103523 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [37].Lansley KE, Winyard PG, Bailey SJ, Vanhatalo A, Wilkerson DP, Blackwell JR, Gilchrist M, Benjamin N, Jones AM. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc 2011;43:1125-31. https://doi.org/10.1249/MSS.0b013e31821597b4 10.1249/MSS.0b013e31821597b4 [DOI] [PubMed] [Google Scholar]
• [38].Bloomer RJ, Fisher-Wellman KH, Tucker PS. Effect of oral acetyl L-carnitine arginate on resting and postprandial blood biomarkers in pre-diabetics. Nutr Metab 2009;6:25. https://doi.org/10.1186/1743-7075-6-25 10.1186/1743-7075-6-25 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [39].Calo LA, Pagnin E, Davis PA, Semplicini A, Nicolai R, Calvani M, Pessina AC. Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage. Int J Cardiol 2006;107:54-60.https://doi.org/10.1016/j.ijcard.2005.02.053 10.1016/j.ijcard.2005.02.053 [DOI] [PubMed] [Google Scholar]
• [40].Bueno R, Alvarez de Sotomayor M, Perez-Guerrero C, Gomez-Amores L, Vazquez CM, Herrera MD. L-carnitine and propionyl-L-carnitine improve endothelial dysfunction in spontaneously hypertensive rats: different participation of NO and COX-products. Life Sci 2005;77:2082-97. https://doi.org/10.1016/j.lfs.2005.01.035 10.1016/j.lfs.2005.01.035 [DOI] [PubMed] [Google Scholar]
• [41].Bertelli A, Conte A, Ronca G, Segnini D, Yu G. Protective effect of propionyl carnitine against peroxidative damage to arterial endothelium membranes. Int J Tissue React 1991;13:41-3. [PubMed] [Google Scholar]
• [42].Bloomer RJ, Smith WA, Fisher-Wellman KH. Glycine propionyl-L-carnitine increases plasma nitrate/nitrite in resistance trained men. J Int Soc Sports Nutr 2007;4:22. https://doi.org/10.1186/1550-2783-4-22 10.1186/1550-2783-4-22 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [43].Bloomer RJ, Tschume LC, Smith WA. Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects. Int J Vitam Nutr Res 2009;79:131-41. DOI: 10.1024/0300-9831.79.3.131 10.1024/0300-9831.79.3.131 [DOI] [PubMed] [Google Scholar]
• [44].Jacobs PL, Goldstein ER, Blackburn W, Orem I, Hughes JJ. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr 2009;6:9. https://doi.org/10.1186/1550-2783-6-9 10.1186/1550-2783-6-9 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [45].Bloomer RJ, Williams SA, Canale RE, Farney TM, Kabir MM. Acute effect of nitric oxide supplement on blood nitrate/nitrite and hemodynamic variables in resistance trained men. J Strength Cond Res 2010;24:2587-92. https://doi.org/10.1519/JSC.0b013e3181e382c0 10.1519/JSC.0b013e3181e382c0 [DOI] [PubMed] [Google Scholar]
• [46].Petroczi A, Naughton DP. Potentially fatal new trend in performance enhancement: a cautionary note on nitrite. J Int Soc Sports Nutr 2010;7:25. https://doi.org/10.1186/1550-2783-7-25 10.1186/1550-2783-7-25 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [47].Naureen Z, Perrone M, Paolacci S, Maltese PE, Dhuli K, Kurti D, Dautaj A, Miotto R, Casadei A, Fioretti B, Beccari T, Romeo F, Bertelli M. Genetic test for the personalization of sport training. Acta Biomed 2020;91:e2020012. https://doi.org/10.23750/abm.v91i13-S.10593 10.23750/abm.v91i13-S.10593 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [48].Vettori A, Paolacci S, Maltese PE, Herbst KL, Cestari M, Michelini S, Michelini S, Samaja M, Bertelli M. Genetic determinants of the effects of training on muscle and adipose tissue homeostasis in obesity associated with lymphedema. Lymphat Res Biol 2021;19:322-33. https://doi.org/10.1089/lrb.2020.0057 10.1089/lrb.2020.0057 [DOI] [PubMed] [Google Scholar]
• [49].Kiani AK, Amato B, Maitz S, Nodari S, Benedetti S, Agostini F, Lorusso L, Capelli E, Dautaj A, Bertelli M. Genetic test for Mendelian fatigue and muscle weakness syndromes. Acta Biomed 2020;91:e2020001. https://doi.org/10.23750/abm.v91i13-S.10642 10.23750/abm.v91i13-S.10642 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [50].Davies KP. Development and therapeutic applications of nitric oxide releasing materials to treat erectile dysfunction. Future Sci OA 2015;1. https://doi.org/10.4155/fso.15.53 10.4155/fso.15.53 [DOI] [PMC free article] [PubMed] [Google Scholar]
• [51].Rytlewski K, Olszanecki R, Korbut R, Zdebski Z. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur J Clin Invest 2005;35:32-7. https://doi.org/10.1111/j.1365-2362.2005.01445.x 10.1111/j.1365-2362.2005.01445.x [DOI] [PubMed] [Google Scholar]
• [52].Wu Z, Satterfield MC, Bazer FW, Wu G. Regulation of brown adipose tissue development and white fat reduction by L-arginine. Curr Opin Clin Nutr Metab Care 2012;15:529-38- https://doi.org/10.1097/MCO.0b013e3283595cff 10.1097/MCO.0b013e3283595cff [DOI] [PubMed] [Google Scholar]
• [53].Witte MB, Kiyama T, Barbul A. Nitric oxide enhances experimental wound healing in diabetes. Br J Surg 2002;89:1594-601. https://doi.org/10.1046/j.1365-2168.2002.02263.x 10.1046/j.1365-2168.2002.02263.x [DOI] [PubMed] [Google Scholar]
• [54].Grimble GK. Adverse gastrointestinal effects of arginine and related amino acids. J Nutr 2007;137:1693S-1701S https://doi.org/10.1093/jn/137.6.1693S 10.1093/jn/137.6.1693S [DOI] [PubMed] [Google Scholar]
• [55].Cynober L. Pharmacokinetics of arginine and related amino acids. J Nutr 2007;137:1646S-1649S. https://doi.org/10.1093/jn/137.6.1646S 10.1093/jn/137.6.1646S [DOI] [PubMed] [Google Scholar]
• [56].Gracia-Sancho J, Lavina B, Rodriguez-Vilarrupla A, Garcia-Caldero H, Fernandez M, Bosch J, Garcia-Pagan JC. Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability. Hepatology 2008;47:1248-56. https://doi.org/10.1002/hep.22166 10.1002/hep.22166 [DOI] [PubMed] [Google Scholar]
• [57].Coman D, Yaplito-Lee J, Boneh A. New indications and controversies in arginine therapy. Clin Nutr 2008;27:489-96. https://doi.org/10.1016/j.clnu.2008.05.007 10.1016/j.clnu.2008.05.007 [DOI] [PubMed] [Google Scholar]
• [58].Schulman SP, Becker LC, Kass DA, Champion HC, Terrin ML, Forman S, Ernst KV, Kelemen MD, Townsend SN, Capriotti A, Hare JM, Gerstenblith G. L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 2006;295:58-64. https://doi.org/10.1001/jama.295.1.58 10.1001/jama.295.1.58 [DOI] [PubMed] [Google Scholar]
• [59].Pitocco D, Zaccardi F, Di Stasio E, Romitelli F, Santini SA, Zuppi C, Ghirlanda G. Oxidative stress, nitric oxide, and diabetes. Rev Diabet Stud 2010;7:15-25. https://doi.org/10.1900/RDS.2010.7.15 10.1900/RDS.2010.7.15 [DOI] [PMC free article] [PubMed] [Google Scholar]